Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.SMC-containing condensin complexes create chromosome topologies essential for mitosis/meiosis, gene expression, recombination, and repair.Many eukaryotes have two condensin complexes (I and II); C.elegans h
Meta-analyses: what they can and cannot do
Meta-analyses overcome the limitation of small sample sizes or rare outcomes by pooling results from a number of individual studies to generate a single best estimate.As long as a meta-analysis is not limited by poor quality of included trials, unexplainable heterogeneity and/or reporting bias of individual trials, meta-analyses can be instrumental
Sustained spatial attention to vibrotactile stimulation in the flutter range: relevant brain regions and their interaction.
The present functional magnetic resonance imaging (fMRI) study was designed to get a better understanding of the brain regions involved in sustained spatial attention to tactile events and to ascertain to what extent their activation was correlated.We presented continuous 20 Hz vibrotactile stimuli (range of flutter) concurrently to the left and ri
poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening
Abstract Background A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy.High-throughput screening (HTS) in drug discovery involves testing a large number of compounds in a biological assay to identify active compounds.Normally, molecules from a large compound library are tested